The use of percentage change from baseline as an outcome ...

Vickers A. J. (2001).The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study. BMC medical research methodology, 1, 6. https://doi.org/10.1186/1471-2288-1-6

The use of percentage change from baseline as an outcome in a controlled trial is statistically inef

Percentage change from baseline should not be used in statistical analysis. Trialists wishing to report this statistic should use another method, such as ANCOVA, and convert the results to a percentage change by using mean baseline scores.

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